Raspberry ketone is an aromatic component present in raspberries and other fruits. Additionally, it may be made artificially in a laboratory.
Scientists had previously found that pungent compounds with similar chemical structures, such as capsaicin and synephrine, had lipolytic activity — causing fat breakdown — in rats fed a high-fat diet and in in vitro fat cells.
In one experiment, to test the impact on obesity, rats were given a high-fat diet plus raspberry ketone for around 10 weeks. Other experiments were performed in vitro (in examination tubes, petri dishes, etc.). Scientists discovered that, compared to controls, raspberry ketone decreased the level of fat in the liver and visceral adipose (abdominal fat) cells of mice. Additionally, it significantly increased norepinephrine-induced lipolysis (the decomposition of fat) in some rat fat cells.
Researchers that they showed greater proof of breakdown when compared to controls found also examined in vitro fat cells with raspberry ketone.
They concluded that raspberry ketone prevents and improves obesity and fatty liver in certain animal models. While the exact mechanism hasn’t been completely understood, these results seem to stem from the activity of raspberry ketone in altering the lipid metabolism, or even more particularly, in escalating norepinephrine-induced lipolysis in white adipocytes (fat cells).
Experts speculate that raspberry ketone influences the energy metabolism using a system much like that of capsaicin. Capsaicin, an element found in chili peppers, has been looked at in people for weight loss.
In another study, the influence of raspberry ketone on energy metabolism was examined by measuring metabolic markers in brown fat tissue, a special sort of fat that generates heat in a process called thermogenesis. These results reportedly indicate that raspberry ketone stimulates the brown fat thermogenesis and increases energy metabolism. In any case, more in depth studies are required to establish a mechanism for raspberry ketone.
Animal models and test tube experiments are important areas of scientific development and innovation, especially at early stages. Positive early results in the laboratory may be promising, but these do not always mean the same benefits may occur in humans.